Influence of scaffold stiffness on subchondral bone and cartilage regeneration in an ovine model of osteochondral defect healing
نویسندگان
چکیده
Influence of scaffold stiffness on subchondral bone and cartilage regeneration in an ovine model of osteochondral defect healing Karin Schlichting1, Devakara R. Epari1, Hanna Schell1, Ralf U. Kleemann1, Andreas Weiler2, Georg N. Duda1 1Center for Musculoskeletal Surgery, Charité University Medicine, Free and Humboldt-University, Berlin, Germany; 2Center for Special Joint Surgery, Berlin, Germany [email protected]
منابع مشابه
Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints.
Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure, consisting of subchondral bone, intermediate calcified cartilage and the superficial cartilage regions. In this study, the long term ability of a multi-layered biomimetic collagen-based scaffold to repair osteochondral defects is investigated in a large an...
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